嗜麦芽寡养单胞菌胞外蛋白酶功能研究进展

Progress on the functions of extracellular proteases from Stenotrophomonas maltophilia-A review

摘要:

嗜麦芽寡养单胞菌(Stenotrophomonas maltophilia)是广泛分布于自然界的革兰氏阴性杆菌。作为一种新型、与高死亡率相关的条件致病菌,嗜麦芽寡养单胞菌能够导致人类或其他生物感染多种疾病。近年来,越来越多的研究结果显示来自于细菌的胞外蛋白酶是导致宿主发病的关键蛋白质。因此,探究嗜麦芽寡养单胞菌胞外蛋白酶的组成成分和功能将不仅有助于阐明其致病机制,更为今后以其为靶点进行临床治疗奠定基础。本文试图对嗜麦芽寡养单胞菌胞外蛋白酶的性质、功能及其应用进行归纳总结。

关键词:嗜麦芽寡养单胞菌;胞外蛋白酶;纤溶;应用

Abstract:

Stenotrophomonas maltophilia is a gram-negative bacilli, widely distributed in the natural environments. As a novel, conditional pathogenic bacterium associated with high mortality, S. maltophilia could infect human or other organisms. In recent years, more and more studies have shown that extracellular proteases from bacteria are the key proteins which could lead to the incidence of hosts. Therefore, to explore the compositions and functions of extracellular proteases from S. maltophilia will not only help elucidate the pathogenic mechanisms, but also provide information on using them as the targets during the clinical treatment in the near future. This paper summarizes the characterizations, functions and applications of the extracellular proteases from S. maltophilia.

Key words:Stenotrophomonas maltophilia;extracellular proteases;fibrinolysis;application