传染性法氏囊病病毒的自然重组

Naturally occurring reassortants of infectious bursal disease virus-A review

摘要:

传染性法氏囊病病毒(Infectious Bursal Disease Virus, IBDV)是双RNA病毒科(Birnaviridae)的典型代表,其引起的传染性法氏囊病(Infectious Bursal Disease, IBD)是危害养禽业的一种重要免疫抑制病和致死性传染病。IBDV的自然重组给疫病防控带来了新风险。本文综述了IBDV基因组节段重组和基因内重组的主要类型,分析了其形成机制及生物学意义,提出了该类病毒遗传演化研究以及疫病综合防控的新思路。

Abstract:

Infectious bursal disease virus (IBDV) is an important representative of Birnaviridae, which causes infectious bursal disease (IBD), one important immuno-suppressive and fatal disease threatening the poultry husbandry. The naturally occurring reassortants of IBDV induced new risks to disease prevention and control. Here, we reviewed the main types of the genome segments reassortants and intragenic recombination, the inherent mechanism and the biological significances were analyzed, which would give us new insights into the virus genetic evolution research and the disease control strategy.