细菌锌离子调控体系与感染

Zinc regulation system in bacteria and its relationship with infection-A review

摘要:

锌（Zn）是生命体不可或缺的微量元素，对细菌和宿主同等重要。细菌体内锌离子稳态的维持依赖锌离子转运和调控体系。宿主通过限制锌离子或高锌离子中毒来控制细菌感染。为了在宿主体内生存，细菌必须表达高亲和力的锌离子转运系统，如ZnuABC，以获取足够的锌离子。由于锌与细菌大量的代谢和毒性通路密切相关，在细菌建立感染的过程中尤为重要，因此通过抑制锌离子转运系统来影响锌离子的稳态，将成为一个非常有发展前途的新型抗菌策略。

关键词:锌;锌离子调控;感染;抗菌治疗

Abstract:

Zinc is an indispensable trace element and important for both bacteria and eukaryotes. Zn homeostasis is established by Zn²⁺ transport and regulation system. Hosts have developed mechanisms for Zn restricting or toxicosis in response to infections. In order to grow and multiply in the infected host, bacteria have progressed strict zinc transportation and regulation system, such as ZnuABC. Zinc is critically involved in a plethora of metabolic and virulence pathways and is paramount important in infection. Therefore, there could be possibilities to use zinc transporters as a very promising target for the development of novel antimicrobial strategies.

Key words:zinc;zinc regulation;infection;antimicrobial treatment