3-磷酸甘油醛脱氢酶在细菌粘附中的作用及机制

Mechanisms of glyceraldehyde 3-phosphosphate dehydrogenaseis in bacteria adhesion-A review

摘要:

3-磷酸甘油醛脱氢酶（GAPDH）是糖酵解中的关键酶，参与糖酵解过程，生成能量。除了这些基本功能，GAPDH还参与tRNA出核、催化微管聚合、调节蛋白质表达与磷酸化、参与自噬等多种其他生理功能。研究表明GAPDH在细菌的黏附中发挥重要作用。本文主要综述GAPDH的基本功能，及其黏附作用与其机制，最后展望了GAPDH研究与应用前景。

Abstract:

Glyceraldehyde 3-phosphosphate dehydrogenaseis (GAPDH) acts as an enzymes of glycolysis and participates in the glycolytic pathway to generate energy. As a "housekeeping" protein, GAPDH is involved in many cellular processes in addition to glycolysis. These functions include DNA repair, tRNA export, facilitating microtubule polymerization, regulating the expression of the protein, and cell autophagy. Many researches indicated that bacterial surface GAPDH is involved in adhesion. This article reviews the basis function of GAPDH, and the role and mechanism of GAPDH in adhesion of bacteria.