多重耐药菌在人类、动物和环境的耐药和传播机制

Antimicrobial resistance and dissemination of multidrug resistant organisms-A review

摘要:

抗生素等抗菌药物的滥用在全球范围内造成了多重耐药菌的传播。多重耐药菌（Multidrug resistantorganisms，MDRO）以及耐药基因（Antibiotic resistance genes，ARGs）可在人类、动物和环境之间进行传播，尤其是ARGs可以通过水平转移的方式在同种属或者不同种属的菌群之间进行传播，使得细菌耐药问题日益严重，耐药机制趋于复杂，疾病治疗更加困难，对人类公众健康造成严重的威胁。因此抗生素等抗菌药物的使用应加以规范。

Abstract:

The abuse of antimicrobial agents has led to the rapid dissemination of multidrug resistant bacteria around the world. The multidrug resistant organisms (MDRO) and antibiotic resistance genes (ARGs) can be transferred among humans, animals and environments. Especially, ARGs can be transferred through a horizontal manner between the same species or different species of bacteria, making the growing problem of bacterial resistance and resistance mechanisms more complex. Moreover, the multidrug resistant organisms with complex resistance patterns have posed an increasing threat to our health. Therefore, the use of antibiotics must be tightly regulated.