肺炎链球菌溶血素的研究进展

Research progress in pneumolysin

摘要:

肺炎链球菌溶血素（Pneumolysin，PLY）是肺炎链球菌的一种重要毒力因子，包含4个结构域，是胆固醇依赖性细胞溶血素（CDCs）的家族成员之一。PLY可广泛作用于宿主组织细胞，发挥细胞毒性作用。PLY可活化补体经典途径，诱导巨噬细胞和单核细胞等产生细胞因子，介导机体免疫应答过程。PLY是肺炎链球菌蛋白疫苗和相关小分子药物研制的重要靶标。本文就PLY的结构、功能及相关疫苗的最新研究进展进行综述。

Abstract:

Pneumolysin is a multifunctional virulence factor expressed by Streptococcus pneumoniae. Pneumolysin includes 4 domains and is a member of cholesterol-dependent cytolysins. Pneumolysin has extensive cytotoxicity to a range of host cells. Furthermore, pneumolysin can activate complement classical pathway, and induce macrophages and monocytes to produce proinflammatory cytokines, mediate host immune responses. Consequently, pneumolysin is a potential candidate target for research and development of vaccines and drugs. In this review, the latest research progresses on the structure and function of pneumolysin, and related vaccines are discussed.