结核分枝杆菌PhoP系统研究进展

Mycobacterium tuberculosis PhoP system

摘要:

PhoP与PhoR组成的PhoPR是结核分枝杆菌重要的双组分调节系统。PhoP作为应答调节子调节基因的表达，这些基因参与细胞壁脂质合成，并对结核分枝杆菌毒力有重要调控作用。本文综述了PhoP的结构、性质以及相关的结核分枝杆菌疫苗研发情况，并提出了未来可能的研究趋势。

Abstract:

PhoPR is an important two-component regulatory system in Mycobacterium tuberculosis. PhoP is essential for virulence as a response regulator involved in cell wall lipid biosynthesis and regulation of gene expression. In this review, the structure, function and vaccine application of PhoP were summarized, as well as some questions that need to be solved.