黏菌代谢产物及其生物活性的研究进展

Metabolites and activities of myxomycetes

摘要:

黏菌代谢产物的研究显示出其较高的应用价值，并取得了较大的进展。本文综述了从黏菌中分离得到的100余个代谢产物，主要包括：脂肪酸、氨基酸、生物碱、萘醌、芳香族化合物、萜类化合物以及酯或其衍生品等。阐述了其抑菌、抗肿瘤、细胞毒及抗氧化活性，简要介绍了化合物的构效关系，同时对黏菌生物活性的研究方法及生物化学特征进行了总结，分析了不同黏菌类群代谢产物的异同。最后对黏菌代谢产物的研究提出了问题与展望。

Abstract:

Research on the metabolites of myxomycetes has previously demonstrated the high potential for practical applications and has made great progress. In this paper, we reviewed more than 100 metabolites isolated from myxomycetes, including fatty acids, amino acids, alkaloids, naphthoquinones, aromatic compounds, terpenoids, esters or derivatives thereof. We also introduced their antimicrobial, antitumor, cytotoxic and antioxidant activities. In addition, the structure-activity relationship of these compounds has been briefly introduced. Furthermore, the biological activity research methods and biochemical characteristics of myxomycetes were also summarized, whilst the differences between the metabolites of various myxomycetes were analyzed. Finally, the problems and prospects of myxomycetes metabolites research have been discussed.