人体肠道病毒组学研究进展

Research progresses in human gut virome

摘要:

人体微生物组计划开展近10年来，大量的研究显示人体微生物通过各种方式深刻地影响着人体健康。人体肠道内丰富多样的病毒构成了肠道病毒组，是人体微生物组的重要组成部分，和人体健康密切相关。本文综述了近些年国际上人体肠道病毒组研究的最新进展，分别从人体肠道病毒组的组成特征、肠道病毒组-细菌组-人体间的相互作用及其对人体健康的影响、病毒组研究的技术策略及挑战等方面进行了论述，探讨了肠道病毒组在人体疾病预防和治疗领域应用的可行性。

Abstract:

Human Microbiome Project has been initiated for 10 years. Many studies revealed the crucial roles of human microbiome in human health and diseases. Human virome including human viruses and bacterial phages is a key component of human microbiome and can be associated with human health. Here, by reviewing the latest research progresses in human gut virome studies, we show the features of human gut virome, interactions between human virome, bacteriome and human cells, impacts on human health, as well as strategies and challenges in human gut virome study. We further explore the feasibility in using human gut virome for medical applications.