分枝杆菌毒素——分枝杆菌内酯与布鲁里溃疡

Mycolactone: the toxin of Mycobacterium and Buruli u

摘要:

溃疡分枝杆菌感染会导致慢性皮肤疾病布鲁里溃疡，引起组织坏死、细胞凋亡和免疫抑制等，感染前期患处会失去痛感从而往往使患者延迟其治疗。聚酮类分子分枝杆菌内酯是其细胞毒性的物质基础，也是分枝杆菌产生的主要毒素，对于免疫细胞和非免疫细胞都具有细胞毒性。本文综述了分枝杆菌内酯的结构、细胞毒性作用和分子靶点等，并提出了有待研究的问题以及研究意义。

Abstract:

Mycobacterium ulcerans infection can cause chronic skin ulceration——Buruli ulcer, leading to tissue necrosis, apoptosis and immune suppression. The relatively painlessness of ulcers during the early stage of infection will delay the treatment for patients. Mycolactone is the cytotoxic basis of M. ulcerans, which targets both immune cells and some nonimmune cells. In this review, the chemical structure, cytotoxicity and molecular targets of mycolactone were summarized, as well as questions for mycolactone.