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glmS核糖开关研究进展
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国家自然科学基金（31670077）


Research progress in glmS riboswitch
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    摘要:

    glmS核酶是存在于革兰氏阳性细菌中，对葡糖胺-6-磷酸（GlcN6P）的合成起反馈抑制作用的核糖开关。同时，glmS核糖开关是一种位于glmS基因5'非翻译区的自剪切核酶。glmS核糖开关/核酶通过结合GlcN6P后自剪切抑制下游基因glmS的表达。对glmS核糖开关结构和功能的研究将有助于开发新的抗生素作用靶点。本文对glmS核糖开关的结构和功能进行阐述并介绍glmS核糖开关近年来的研究进展和应用。

    Abstract:

    The glmS ribozyme is predominantly present in gram-positive bacteria, and it is a riboswitch that inhibits the synthesis of glucosamine-6-phosphate. In addition, glmS riboswitch is a self-cleft ribozyme located in the 5' untranslated region of the glmS gene. Study on the structure and function of glmS riboswitch will be beneficial to develop new targets for antibiotic action. In this paper, we reviewed the structure and function of glmS riboswitch. In addition, we also introduce recent research progress and application of glmS riboswitch.

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周丁,王倩,祁庆生. glmS核糖开关研究进展[J]. 微生物学报, 2017, 57(8): 1151-1159

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  • 收稿日期:2017-03-20
  • 最后修改日期:2017-04-22
  • 在线发布日期: 2017-08-10
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