胶霉毒素的研究进展

Progress in the research of gliotoxin

摘要:

胶霉毒素（gliotoxin，GT）是一个分子量为326 Da的小分子化合物，其骨架是由非核糖体肽合成酶GliP催化苯丙氨酸和丝氨酸缩合成的环二肽，属于表聚硫代哌嗪二酮类化合物，是一种重要的真菌次级代谢产物。体内外研究已经表明，GT对动植物产生多种效应，不仅具有免疫抑制功能和诱导细胞凋亡作用，在生物防治方面也具有潜在的应用价值。本文将对有关GT生物合成、诱导宿主效应机制及其潜在应用价值进行综述。

Abstract:

Gliotoxin is a small molecular compound with a molecular weight of 326 Da, and its skeleton is a cyclic two-peptide synthesized by the non-ribosomal peptide synthetase GliP, catalyzing the condensation reaction of phenylalanine and serine. Gliotoxin belongs to the family of epidithiodiketopiperazines, is an important fungal secondary metabolite. Many studies have shown that gliotoxin has a variety of effects on plants and animals both in vivo and in vitro. Gliotoxin not only has the function of immune suppression, inducing host cell apoptosis, but also has potential application in biological control. The recent advances in biosynthesis process, mechanisms of gliotoxin on host cells and its potential application value are reviewed in this paper.