细菌三型分泌系统效应蛋白转运的研究进展

Advances in studies of translocation of effector by bacterial type 3 secretion system

摘要:

三型分泌系统（Type 3 secretion system，T3SS）作为存在于革兰氏阴性菌中的分泌系统之一，对革兰氏阴性菌的致病有重要作用。T3SS的致病作用体现在T3SS能直接将效应蛋白转运至宿主细胞，进而通过效应蛋白调控细胞的一系列通路，促进细菌定殖于细胞。而效应蛋白的转运受到两方面因素的调控，一方面是效应蛋白本身的信号序列，另一方面是T3SS相关蛋白的辅助。本文围绕近年来T3SS的构成、效应蛋白转运机制方面的最新进展进行概要综述。

Abstract:

Type 3 secretion system, as one of the secretion systems for Gram-negative bacterial, plays an important role in the pathopoiesia of Gram-negative bacteria. Bacteria can use T3SS as a canal that directly translocates effectors to host cell. Effectors in host cell manipulate a subset of signaling pathways of host cell to promote bacterial colonization in cells. The translocation of effectors is regulated by two factors, one is the signal sequences of effector, and the other is the regulation of T3SS-associated proteins. In this article, we review recent advances in studies on the constitute of T3SS and the mechanism of effectors translocation.