革兰氏阴性菌脂蛋白Lol系统转运蛋白的功能及表面展示分泌机制

Functions of Lol system proteins and surface-exposed mechanisms of lipoproteins in gram-negative bacteria

摘要:

细菌脂蛋白是细胞膜的重要组成成分，在革兰氏阴性菌的生理及致病性中扮演着重要的角色。革兰氏阴性菌中已知负责胞内脂蛋白转运的是Lol（Localization of lipoprotein）系统。该系统识别成熟脂蛋白的分泌信号，将外膜脂蛋白转运并定位于细胞外膜内侧。近年来的研究发现，跨细胞外膜进行表面展示的脂蛋白实际上在革兰氏阴性菌中广泛存在，其分泌机制开始成为研究热点。为了对革兰氏阴性菌中脂蛋白分泌机制的研究现状有一个系统全面的了解，本文概述了脂蛋白转运过程中Lol系统5个转运蛋白的功能与保守性、不同细菌中脂蛋白分泌信号的差异以及表面展示脂蛋白可能的分泌机制。

Abstract:

Bacterial lipoproteins are important components of cell membrane. They play important roles in bacterial physiology and virulence in gram-negative bacteria. The Lol (localization of lipoprotein) pathway discovered from E. coli is responsible for the transport of lipoprotein in gram-negative bacteria. Recent research found that surface-exposed lipoproteins are widespread in gram-negative bacteria. To better understand the current studies of lipoprotein secretion mechanisms in gram-negative bacteria, we reviewed functions and conservation of five Lol proteins, the difference of lipoprotein secretion signals in variant bacteria and possible transport mechanisms of surface-exposed lipoproteins.