丝状真菌胞吐体的研究进展

Advances in exocyst complex in filamentous fungi

摘要:

胞吐体（Exocyst）是真核生物细胞内由8个亚基组成的复合体，在后高尔基体产生的分泌囊泡与细胞膜特定位置的定向与拴系过程中发挥重要作用。一些小G蛋白通过直接与胞吐体的亚基相互作用，对极性胞外分泌进行精确的时空调节。丝状真菌的生长是通过菌丝顶端的极性生长来完成的，并且具有极强的分泌蛋白质能力，是研究胞吐体的理想系统。胞吐体对丝状真菌的形态发生和致病性都有极大的影响。本文综述了当前在丝状真菌中胞吐体的研究进展，包括它的组成、亚基定位、相关功能和调控。

关键词:丝状真菌;胞吐体;极性生长;致病性

Abstract:

Exocyst is an octameric protein complex that plays a crucial role in the docking and tethering of post-Golgi secretory vesicles to the plasma membrane in eukaryotic cell. The subunit of exocyst complex directly interacts with small GTPases and provides precise spatiotemporal regulation in polarized exocytosis. The growth of filamentous fungi is accomplished by polarized growth in hypha tip, and it possess strong ability of protein secretion. Filamentous fungi are ideal experimental system in study exocyst complex. Exocyst affects morphogenesis and pathogenesis in filamentous fungi. This review summarized current research on exocyst complex in filamentous fungi, including its composition, localization of subunit, function and regulation.

Key words:filamentous fungi;exocyst;polarized growth;pathogenesis