沙门菌效应蛋白对宿主细胞的影响及分子机制

Roles of Salmonella effectors in manipulating host cell function

摘要:

沙门菌（Salmonella spp.）作为胞内病原菌，通过侵入宿主细胞，导致人类和多种动物感染疾病。在与宿主细胞的长期斗争中，沙门菌进化出多种机制来逃避宿主的监视与防御，从而完成侵入并生存增殖的过程。尽管一些效应蛋白靶向的宿主因子已经被发现，但大多数效应蛋白的靶点尚且未知。本文综述了沙门菌效应蛋白对宿主细胞生理活动的影响，包括对细胞骨架的变化、炎症应答、胞膜修饰和滤泡的胞内移动现象及其分子机制进行阐述。

Abstract:

Salmonella is an intracellular bacterial pathogen that infects both humans and animals. After a long time of hard struggle, Salmonella has evolved numerous mechanisms to evade host immune defenses, and finally accomplished the process of invasion and replication. Although some of the host targets manipulated by Salmonella effectors have been identified, the interaction between Salmonella and host cells remains unclear. This review summarizes the functions and mechanisms of Salmonella effectors in regulating the host cell signaling pathways, including cytoskeletal changes, inflammatory responses, membrane modifications and vacuolar trafficking.