LC3相关吞噬作用与病原微生物感染

LC3-associated phagocytosis and microbial infections

摘要:

LC3相关吞噬作用（LC3-associated phagocytosis，LAP）是一种宿主细胞吞噬和降解病原体的高效过程。近年来越来越多的研究表明，LAP在清除病原微生物感染过程中具有非常重要的作用，其作用机制不同于传统的吞噬作用和自噬作用。在外源刺激下，宿主细胞通过招募自噬相关的蛋白实现LC3向单层膜吞噬泡的聚集，从而提高其吞噬和杀伤病原体的效率。不同病原微生物应对LAP的杀伤作用的方式是不同的，本文对LAP发生的一般规律、各种微生物感染过程中LAP发生的不同情况及其近期研究进展予以综述。

Abstract:

LC3-associated phagocytosis (LAP) is an efficient process for the phagocytosis and degradation of invading pathogens. Recently, many studies show that LAP plays a very important role in the elimination of pathogenic microorganism, and its mechanism is different from the conventional phagocytosis and autophagy. Upon the extracellular stimulation, the activation of some autophagy related proteins in host cells induces the recruit of LC3 to the single membrane of phagosome, which promotes the efficiency of phagocytosis and killing of the pathogens. Different pathogens have different mechanisms to cope with the killing of LAP. The general mechanism of LAP, different responses to LAP to various pathogens and the research progress in recent years are reviewed in this paper.