细菌非编码RNA及其分子伴侣Hfq

Non-coding RNA and RNA chaperone Hfq in bacteria

摘要:

细菌在生存过程中要面对复杂多样的环境，在长期进化过程中，细菌逐渐形成不同的应答机制来感应环境信号的变化，并通过精确的基因表达来调控生理生化反应。基因表达调控可分为转录水平和转录后水平两个方面，对于细菌来说，非编码RNA在转录后调控上发挥着重要的作用，而大多数非编码RNA与靶标mRNA的相互作用过程又离不开Hfq蛋白的辅助。本文综述了非编码RNA的分类、调控特点，伴侣蛋白Hfq的结构、功能以及两者相互作用的机制，以期深入了解非编码RNA及其伴侣蛋白Hfq在转录后调控中发挥的作用。

Abstract:

Bacteria have to adapt complex environment for survival in nature. For this environmental fitness, bacteria generate different response mechanisms to perceive environmental signals for regulating cell physiological and biochemical reaction in the long-term evolution process. Gene expression regulation is one of the response mechanisms with the transcription level and the post-transcriptional level. Non-coding RNAs (ncRNAs) play an important role in the post-transcriptional regulation in bacteria. Hfq is required for the action of many ncRNAs that act by base-pairing with target mRNAs. This review summarizes the function of ncRNAs and Hfq in post-transcriptional regulation, including:1. the classification and characteristics of ncRNAs; 2. the structure and function of Hfq protein; 3. non-coding RNAs and Hfq interaction.