肠道微生物与线粒体之间的互作

Advances in interactions between gut microbiota and mitochondria

摘要:

肠道微生物与肠道细胞线粒体功能之间的关系十分密切。一方面，肠道微生物可直接或通过短链脂肪酸、硫化氢和一氧化氮等代谢产物间接影响与线粒体相关的能量代谢过程，调节线粒体活性氧的产生，调控线粒体甚至整个机体的免疫反应。另一方面，肠道细胞线粒体功能紊乱和基因组的遗传变异也会影响肠道微生物的组成和功能。本文主要介绍了肠道微生物和线粒体之间的互作关系的最新研究进展，为靶向作用于肠道菌群和线粒体以调节肠道健康提供理论依据。

关键词:肠道微生物;线粒体;能量代谢;活性氧;免疫

Abstract:

The relationship between gut microbiota and mitochondria is very close. On the one hand, intestinal microorganisms can directly or indirectly through the digestion of nutrients in food to produce metabolites such as short-chain fatty acids, hydrogen sulfide and nitric oxide, affect the energy metabolism process associated with mitochondria, regulate mitochondrial reactive oxygen species production, and regulate mitochondria and even the entire body's immune response. On the other hand, intestinal cell mitochondrial dysfunction and mitochondrial genome genetic variation also affect the composition and function of the gut microbiota. In this paper, we summarized recent advances in the relationship between gut microbiota and mitochondria. It provides a theoretical basis for targeting the intestinal flora and mitochondria to regulate intestinal health.

Key words:gut microbiota;mitochondria;energy metabolism;reactive oxygen;immunity