乳酸菌群体感应与其肠道生物膜形成的研究进展

Progress in research on quorum sensing and intestinal biofilm formation of Lactobacillus

摘要:

肠道内栖息着数量庞大且复杂的微生物菌群，是一个具有生物多样性的微环境，菌群在调节宿主肠道健康中发挥着重要作用。群体感应（quorum sensing，QS）是细菌间通过化学信号分子进行信息传递的重要方式。本文综述了QS系统组成、信号转导机制及AI-2/LuxS系统对肠道生物膜形成的调控，介绍了乳酸菌AI-2/LuxS QS系统及其在调控生物膜形成上的作用。通过肠道乳酸菌QS与生物膜形成综述分析，旨在为肠道屏障功能和健康调控提供新思路。

关键词:肠道;群体感应;生物膜;乳酸菌

Abstract:

The intestine is a complicated microenvironment and hosts a large and complex flora of microorganisms, which plays an important role in host gut health. Quorum sensing is an important mechanism of information transmission among bacteria through chemical signal molecules. This article reviews the composition of quorum sensing system, signal transduction mechanism and the regulation of intestinal biofilm formation by AI-2/LuxS quorum sensing system. This review introduces the lactic acid bacteria AI-2/LuxS quorum sensing system and its role in the regulation of biofilm formation in intestine. The review will evoke new ideas for renovation of intestinal barrier function and intestinal health regulation.

Key words:intestine;quorum sensing;biofilm;Lactobacillus