抗生素耐药性的多重风险因子及针对性管控策略

Key risk factors of antibiotic resistance ecology and targeted control strategies

摘要:

抗生素耐药性已经对人类社会造成了重大影响，需要采取切实有效的管控措施，本文将针对耐药性研究领域的新视角，回顾了亟需重视的抗生素耐药性多重风险因素，包括非致病菌、食源和肠道菌群、粪便菌群、废水处理、用药途径和生物膜等，强调了口服抗生素的危害。通过总结针对性的耐药和疾病防控策略，为有效应对抗生素耐药性危机提供新思路。

关键词:抗生素耐药性风险因子;耐药性管控;共生菌群;肠道菌群;给药途径

Abstract:

Antibiotic resistance has caused major damages to public health and social economy, and effective control has become a stressing need. This review summarizes recent changes in the scope and methods of antibiotic resistance investigation, and discusses the contributions of foodborne bacteria, gut, fecal and waste water microbiota, drug administration routes, and biofilm to the mega antibiotic resistance problem seen today. We also present new directions for mitigation of antibiotic resistance and diseases.

Key words:antibiotic resistance risk factors;antibiotic resistance mitigation;commensal microbiota;gut microbiota;drug administration method