PstS和PstB调控无机磷酸盐转运和介导细菌耐药的机制

Regulating inorganic phosphate transport and mediating bacterial resistance by PstS and PstB

摘要:

无机磷酸盐（Pi）在菌体遗传、能量代谢及细胞内的信号传导等生物过程中发挥重要的作用。在细菌中，主要由磷酸盐特殊转运系统（Pst）和磷酸盐转运系统（Pit）来完成对Pi的吸收和利用。其中，Pst是在低磷胁迫下转运Pi的关键系统。近年来的研究表明，Pst系统除在调控Pi的代谢和平衡中发挥重要作用外，还介导细菌耐药、产毒和侵袭等。Pst系统是ABC转运蛋白家族的一种，一般由PstS、PstC、PstA、PstB和PhoU 5个蛋白组成。其中，PstS和PstB蛋白是该系统中的关键蛋白。本文重点对PstS和PstB调控Pi转运和介导细菌耐药的分子机制进行综述，旨在为深入研究该系统与细菌耐药的关系，以及研发以PstS和PstB为靶点的新药提供参考。

Abstract:

Inorganic phosphate (Pi) plays an important role in the biological processes such as bacterial heredity, energy metabolism and intracellular signaling. Two major bacterial Pi import systems exist in bacteria, Pst and Pit. The Pst system is highly efficient at transporting Pi, particularly in cells growing under low-Pi concentrations. In recent years, studies have found that in addition to regulating metabolism and balance of Pi, Pst system also mediates drug resistance, toxicity and invasion of bacteria. The Pst system is a member of the ABC transporter family, generally consists of five distinct proteins of PstS, PstC, PstA, PstB and PhoU. Among them, PstS and PstB are key proteins in the Pst system. This article reviews the molecular mechanisms of Pi transport and bacterial resistance of PstS and PstB, and the relationship between Pst system and bacterial resistance as well as PstS/PstB-targeted development to manufacture new drug.