红藻凝集素G研究进展

Research progress of griffithsin

摘要:

来源于海洋红藻的凝集素G已被证实对多种囊膜病毒都有抗病毒活性，可与囊膜病毒表面糖基结合而阻断病毒的入侵。以病毒入侵为作用靶点的抗病毒药物，不仅可以阻断病毒的自由传播途径，还可以阻断细胞间传播途径，红藻凝集素G还具有可溶性好、易表达、稳定性强、免疫原性低、安全性好等优点，所以红藻凝集素G作为一类新型抗病毒药物越来越受到科学家的青睐。

Abstract:

Griffithsin, originally isolated from Griffithsia spp. marine red algae., is a broad-spectrum antiviral lectin that inhibits viral entry through binding to viral glycoproteins. Drugs that inhibit virus's entry prevent infection of cells by cell-free virus particles and also prevent virus transmission between virus-infected and uninfected cells. Besides, griffithsin also has the advantages of good solubility, easy expression, strong stability, low immunogenicity and good safety. Thus, griffithsin, as a new potential class of antiviral drugs, has got the favor of scientists.