灵杆菌合成灵菌红素的转录调控

Research progress in transcriptional regulation of prodigiosin biosynthesis in Serratia marcescens

摘要:

灵菌红素是一种具有多种生物活性的红色素，具有巨大的经济价值和广阔的应用前景。灵杆菌是灵菌红素的生产菌株，同时也是研究灵菌红素合成的模式菌株。本文综述了转录水平上调控灵杆菌合成灵菌红素的研究进展，总结了双（多）组分调控系统、群体感应系统、σ因子和转录因子在调控灵杆菌合成灵菌红素过程中发挥的作用，并对未来的研究方向进行了展望。

Abstract:

Prodigiosin is a red pigment with multiple biological activities, and of great economic value with promising application. Serratia marcescens is a major producer of prodigiosin, and the model organism for prodigiosin biosynthesis research. This paper reviews recent progresses in transcriptional regulation of prodigiosin synthesis in S. marcescens, illustrating the function of two/multiple component system, quorum sensing system, σ factor and transcriptional regulator in modulating prodigiosin biosynthesis. Moreover, further research focuses are discussed.