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首页 > 过刊浏览>2020年第60卷第3期 >421-430. DOI:10.13343/j.cnki.wsxb.20190245
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L-鸟氨酸发酵菌种的代谢工程研究进展
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江西农业大学博士科研启动基金；国家自然科学基金（31660019）


Advances in metabolic engineering of L-ornithine producing strains
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    摘要:

    L-鸟氨酸是一种非蛋白类氨基酸参与尿素代谢及生物多胺类的合成，其对人体具有治疗肝脏疾病、增强免疫力等作用，被广泛应用于医疗、保健、食品等领域。工业上生产鸟氨酸主要有化学法、酶法及工业发酵法。其中，发酵法因其生产成本及环境保护等方面的优势而逐渐成为研究的焦点。本文归纳了近年来采用基因工程技术选育鸟氨酸高产菌种最新研究进展，重点讨论了产鸟氨酸谷氨酸棒杆菌的代谢工程改造策略，并对未来的研究方向进行了预测。

    Abstract:

    L-ornithine is a non-protein amino acid involved in urea metabolism and polyamines biosynthesis. Due to the positive functions in treating liver diseases and enhancing immunity, L-ornithine is widely used in medicine and food industry. Currently, L-ornithine production mainly depends on chemosynthesis, enzymatic catalysis and microbial fermentation. Among them, microbial fermentation has gradually become the focus for L-ornithine production owing to its superiority in cost and environmental protection. In this article, recent progress in the development of high L-ornithine producing strains through genetic engineering is summarized, the metabolic engineering strategies for improving L-ornithine production in Corynebacterium glutamicum are discussed, and the future direction is predicted.

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徐心怡,张斌,吴晓玉,江燕,陈雪岚. L-鸟氨酸发酵菌种的代谢工程研究进展[J]. 微生物学报, 2020, 60(3): 421-430

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  • 收稿日期:2019-06-02
  • 最后修改日期:2019-08-03
  • 在线发布日期: 2020-03-11
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