细菌在胃肠道肿瘤发生中的作用及其机制

Role of bacteria in the development and progression of gastrointestinal tumors

摘要:

胃肠道肿瘤具有较高的发病率和死亡率，其防治已成为重要的公共卫生问题。胃肠道内的菌群常参与机体的代谢和免疫反应，协同维持机体的平衡状态。多项研究发现消化道内细菌种类和数目的变化在胃肠道肿瘤的发生和发展中具有重要作用。细菌可通过毒力因子、生物膜、代谢产物等多种因素参与致肿瘤作用，甚至影响化疗药物的疗效，然而，细菌在肿瘤发生中的作用地位尚不明确。因此，本文对细菌致胃肠道肿瘤发生发展的机制进行综述，以期为胃肠道肿瘤的早期防治提供理论依据。

关键词:毒力因子;生物膜;微生态;免疫调节

Abstract:

The prevention and treatment for gastrointestinal tumors have become an important public health issue due to the high morbidity and mortality. Microflora in the gastrointestinal tract usually participate in the metabolism and immune response to maintain body homeostasis. Recent studies have found that a variety of bacteria in the gastrointestinal tract play an important role in the occurrence and development of gastrointestinal tumors. Bacteria could induce tumors by virulence factors, biofilm, metabolites and other factors. The efficacy of chemotherapeutic agents could be affected as well. However, the involvement of bacteria in tumorigenesis remains unclear. Therefore, this paper reviews the mechanisms of gastrointestinal tumors induced by bacteria, thereby providing the theoretical basis for early prevention and treatment.

Key words:virulence factors;biofilm;microecology;immunomodulation