嗜粘蛋白阿克曼菌在糖尿病和肥胖中的作用

Role of Akkermansia muciniphila in diabetes and obesity

摘要:

肠道微生物在平衡健康与疾病的过程中起着重要作用。嗜粘蛋白阿克曼菌（Akkermansia muciniphila）是肠道微生物中的一种，其在降解肠道粘蛋白方面的特性使其成为肠腔与宿主细胞黏膜界面的关键生物。嗜粘蛋白阿克曼菌与肥胖、糖尿病、心血管代谢疾病和低度炎症呈负相关。口服嗜粘蛋白阿克曼菌可改善小鼠代谢疾病的相关症状，嗜粘蛋白阿克曼菌有望成为治疗2型糖尿病和肥胖的候选药物。本综述通过总结现有关于嗜粘蛋白阿克曼菌在糖尿病和肥胖症中发挥作用的研究，指出嗜粘蛋白阿克曼菌调节宿主和肠道微生物群之间相互作用可能存在的机制，为嗜粘蛋白阿克曼菌的进一步研究和糖尿病的新药研发提供思路。

关键词:嗜粘蛋白阿克曼菌;糖尿病;肥胖

Abstract:

Gut microbiota plays a significant role in the balance between health and disease. Akkermansia muciniphila is one of the intestinal bacteria and its specialization in mucin degradation makes it a key organism at the mucosal interface between the lumen and host cells. A. muciniphila is found inversely associated with obesity, diabetes, cardiometabolic diseases and low-grade inflammation. Oral administration of A. muciniphila reduces the symptoms of metabolic disease in mice. Therefore, A. muciniphila is a promising candidate for the treatment of diabetes and obesity. Here, we summarize the existing data on A. muciniphila and its role in diabetes and obesity, to provide insight into the intricate mechanisms of A. muciniphila regulation of the cross-talk between the host and gut microbiota, so as to provide ideas for further research on A. muciniphila bacteria and the development of new drugs for diabetes.

Key words:Akkermansia muciniphila;diabetes;obesity