III型干扰素相关生物学功能的研究进展

Update of the biological functions of type III interferon

摘要:

干扰素（Interferon，IFN）是一类具有多功能生物活性的糖蛋白，包含3个家族（I型、II型和III型）。III型干扰素（Type III interferon，IFN-III）是近16年发现的新型干扰素，其诱导过程及生物学功能与I型干扰素（Type I interferon，IFN-I）相似，在抗病毒、免疫调节、抗肿瘤、抑制自身免疫病、抑制过敏性哮喘以及抗细菌和真菌等方面具有重要作用。本文将从IFN-I和IFN-III的分类、序列同源性和信号传导等方面进行阐述，并结合近年来IFN-III在疾病治疗过程中所取得的成就，综述IFN-III的生物学功能，旨在为IFN-III的深入研究以及在多种疾病的诊断和防控中提供参考。

Abstract:

Interferon (IFN) is a kind of glycoprotein with multifunctional biological activity, and contains three families (type I, type II and type III). Type III interferon (IFN-III) is a novel interferon discovered in the last 16 years. The induction process and biological functions of IFN-III are similar to those of type I interferon (IFN-I). IFN-III plays an important role in antiviral, immunomodulatory, antitumor, suppression of autoimmune diseases, allergic asthma, as well as antibacterial and antifungal. We elaborate here IFN-I and IFN-III in terms of classification, sequence homology and signal transduction. Combining with the achievements of IFN-III in the treatment of diseases in recent years, we try to summarize the related biological functions of IFN-III, to provide a reference for further study of IFN-III.