副溶血性弧菌耐热性直接溶血素(TDH)的研究进展

Advances in research on thermostable direct hemolysin (TDH) of Vibrio parahaemolyticus

摘要:

副溶血性弧菌（Vibrio parahaemolyticus）是海产品中一种常见的食源性致病菌，常导致水产养殖动物患病或者引起食物中毒。耐热性直接溶血素（thermotolerant direct hemolysin，TDH）是副溶血性弧菌最为重要的致病因子之一。本文围绕tdh基因在弧菌属中的广泛分布与传播、tdh基因的多样性及其表达调控、TDH的蛋白结构及其生物活性进行了综述，并对未来TDH的研究方向进行了展望。旨在进一步了解由副溶血性弧菌感染所引起的病症，为预防副溶血性弧菌的感染和临床治疗提供理论支撑。

Abstract:

Vibrio parahaemolyticus is a widely distributed foodborne pathogen in seafood, often leading to diseases in aquaculture animals or food poisoning for human beings. Thermotolerant direct hemolysin (TDH) is one of the most important virulence factors of V. parahaemolyticus. This article systematically reviews the widespread distribution, spreading, the diversity and expression regulation of tdh gene, as well as the structure, biological activity and promising research directions of TDH protein. The article aims to deeply understand the symptoms caused by V. parahaemolyticus infection, and hence to provide theoretical support for the prevention and clinical treatment of V. parahaemolyticus infection.