DEAD-box RNA解旋酶家族在天然免疫应答信号通路中的作用

DEAD-box RNA helicase family in innate immune response signaling pathway

摘要:

病毒入侵宿主细胞时，宿主细胞启动抑制病毒复制的免疫机制。同样，病毒也会利用多种手段去逃避先天免疫感应机制的监测以及宿主细胞对外来者的降解，同时还会操纵宿主细胞为自身的增殖提供便利。DEAD-box解旋酶家族是一类存在于宿主细胞中的功能蛋白，它们在转录、剪接、mRNA的合成和翻译等多种细胞过程中起着关键作用。该家族成员拥有识别RNA的能力以及参与多个细胞过程，所以它们可以以多种方式影响病毒感染宿主细胞后引起的天然免疫应答。本文就近年来有关于DEAD-box RNA解旋酶在天然免疫方面的研究进行综述，以期为相关研究提供材料支撑。

Abstract:

The innate immune system is the first line of defense against viral infection. Upon virus infection, host cells trigger immune response and initiate the immune mechanism of inhibiting virus replication. Meanwhile, viruses have evolved various mechanisms to counteract the host innate immune signaling pathway, including evading from host pathogen recognition receptors recognition and hijack host proteins to facilitate their own proliferation. DEAD (Asp-Glu-Ala-Asp, DexD/H) helicase family is a class of functional proteins existing in host cells. They play a key role in various cellular processes, such as transcription, splicing, mRNA synthesis and translation. Members of this family have the ability to recognize RNA and participate in multiple cellular processes, so they can affect the innate immune responses caused by viral infection in many ways. This paper reviews the research on DEAD-box RNA helicase in innate immunity to provide reference for related studies.