代谢组学技术在微藻研究中的应用

Application of metabolomics approaches in microalgae research

摘要:

代谢组学（metabolomics/metabonomics）是系统生物学的重要组成部分之一，主要通过分析生物体受环境刺激、病理生理或基因变异等因素引起的内源性小分子代谢物变化来研究其生理功能与代谢之间的关系，进而揭示代谢物变化背后的代谢调控机制与机理。代谢组学技术具有灵敏度高、选择范围广和分析速度快等特点，逐渐在微藻研究领域发挥出优势。本文介绍了代谢组学的研究流程、分析方法以及代谢组学在微藻领域的应用和发展趋势，并提出了代谢组学在微藻研究过程中面临的问题和挑战，以期为代谢组学技术在微藻生物能源利用、环境保护、生产高价值产物等方面的应用提供新的思路和选择。

Abstract:

Metabolomics has become one of the most important areas in systems biology, to qualitatively and quantitatively analyze all endogenous metabolites and reveal the relationship between physiological/pathological changes or environmental perturbation and biological metabolism. Metabolomics has the characteristics of high sensitivity, wide selection range and fast analysis speed, and so it plays an increasing role in the microalgae studies. In this review, we summarize the research process, analysis methods, development trends and challenges of metabolomics in microalgae researches, to provide new ideas and strategies for bioenergy utilization, environmental protection, and high-value bioproducts of microalgae.