2025年6月12日 周四
首页 > 过刊浏览>2021年第61卷第7期 >1882-1895. DOI:10.13343/j.cnki.wsxb.20200531
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cGAS-STING信号通路：免疫监视的重要机制
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国家自然科学基金（32072854，32072855）


cGAS-STING signaling pathway: important mechanisms of immune surveillance
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    摘要:

    免疫系统识别病原微生物的主要机制之一是识别其核酸。环磷酸鸟苷-腺苷合成酶（cGAS）是一种胞质DNA感受器，感知病原DNA后激活cGAS-STING通路。该通路不仅介导天然免疫应答以抵抗多种含DNA的病原微生物感染，还能感知肿瘤来源的DNA而产生抗肿瘤免疫应答。然而，自体DNA对cGAS-STING通路的异常激活也会导致自身免疫性和炎症性疾病。本文综述了cGAS-STING信号通路及其在抗病毒天然免疫中的调控作用与功能，阐述了cGAS-STING通路在抗病毒感染和疾病中发挥的作用。

    Abstract:

    The recognition of microbial nucleic acids is a major mechanism by which the immune system detects pathogenic microorganisms. Cyclic guanosine phosphate adenosine synthase is a cytoplasmic DNA sensor that activates the CGAS-STING pathway after sensing pathogenic DNA. The cGAS-STING pathway not only mediates innate immune response against infections by a large variety of DNA-containing pathogens, but also senses tumor-derived DNA to generate intrinsic antitumor immunity. However, aberrant activation of the cGAS-STING pathway by autologous DNA can also lead to autoimmune and inflammatory diseases. The paper reviews the cGAS-STING signaling pathway and its regulation and functions in antiviral innate immunity, and expounds the role of the cGAS-STING signaling pathway in defensing viral infections and diseases.

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周萍萍,王涛,孙元,仇华吉. cGAS-STING信号通路：免疫监视的重要机制[J]. 微生物学报, 2021, 61(7): 1882-1895

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  • 收稿日期:2020-08-13
  • 最后修改日期:2020-11-10
  • 在线发布日期: 2021-07-07
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