果蝇肠道共生菌对宿主作用的研究进展

Research progress on the effect of symbiotic bacteria in Drosophila gut on its host

摘要:

肠道共生菌是动物体内的重要组成部分，在宿主的生长发育和健康等方面发挥着重要作用，近年来已成为国内外的研究热点。果蝇作为研究肠道微生物菌群功能的优秀模型，在肠道共生菌与宿主关系研究方面已取得许多重要进展。在本文中，我们首先对果蝇肠道微生物的组成和特征作了总结，然后对果蝇肠道共生菌在其生长发育、营养与代谢、行为反应、寿命以及免疫与疾病方面的作用进行了综述，以期为研究人类肠道共生菌功能和肠道健康提供一定理论依据和新的思路。

Abstract:

It is believed that symbiotic bacteria in the gut form an important part of animals, which play a significant role in the growth, development and health of the host. In recent years, it has attracted more attention on a national and international level. Drosophila melanogaster is an excellent model for studying the function of intestinal flora and has made important progress in the relationship between symbiotic gut bacteria and their host. In this paper, we first summarized the composition and characteristics of intestinal microbes in Drosophila, we then reviewed the roles of symbiotic fly gut bacteria on the host growth and development, nutrition and metabolism, behavioral response, longevity, immunity and disease. This will provide some theoretical rationales and new ideas for the study of the function of the gut symbiotic bacteria and the gut health in human.