肠道微生物在肝细胞癌发生发展中的作用机制及其作为诊断指标的可行性

Role and mechanism of intestinal microorganisms in the development of hepatocellular carcinoma and its feasibility as a diagnostic index

摘要:

尽管肝细胞癌和肠道微生物群落之间的关系已得到实验和临床证实，但目前这些关系在指导临床诊断和治疗上的应用仍十分罕见。本文就肠道微生物群落与肝细胞癌的关系及其在肝细胞癌诊断中的应用进行综述，并阐述了当前阻碍肠道微生物群落分析用于肝细胞癌诊断的主要因素。此外，我们还讨论了一种新的肠道微生物群落综合指标用于肝细胞癌诊断的可行性和实用性，尽管该指标中使用的细菌类群仍然值得进一步优化。最后，我们对用于该指标计算的细菌类群的筛选提出了建议。

关键词:肠道菌群紊乱;肠道菌群紊乱度;肠道菌群;肝细胞癌;脂多糖;Toll样受体

Abstract:

Although the relationship between hepatocellular carcinoma and intestinal microbiota has been experimentally and clinically confirmed, its ramifications regarding clinical diagnosis and therapy remain unknown. In this review, we elucidated the relationship between the intestinal microbiota and hepatocellular carcinoma as well as the obstacles to its use in the diagnosis of the latter. Moreover, we discuss the feasibility and usefulness of a novel comprehensive indicator of intestinal microbiota for the diagnosis of hepatocellular carcinoma, even though the bacterial taxa used in this indicator warrant further study. Finally, we provide suggestions for the screening of the bacterial taxa used in the calculation of this indicator.

Key words:diagnosis;degree of dysbiosis;gut microbiota;hepatocellular carcinoma;lipopolysaccharide;Toll-like receptor