微生物酶数据库的发展与应用

Development and applications of enzyme databases

摘要:

可数据化是现代生命科学研究，尤其是合成生物学的一项关键特性。酶作为生命体内催化生化反应的关键分子，其数据化对推动生命科学的基础研究和实际应用都有重要意义。当下商品化的酶大都来源于微生物，建立微生物酶资源数据库不仅可以为酶的分类提供标准参考，还可以指导新型催化元件的挖掘、改造与从头设计。本综述对国际上已有的酶资源数据库建设与发展作了简要介绍，并对基于数据库的微生物酶资源利用作出展望。

Abstract:

Enzymes catalyze most biochemical reactions in living organisms, and the high efficiency, chemo-, regio- and stereoselectivity make enzymes appealing catalysts in many fields. The digitalization of enzyme-related information is of great importance to both academic research and industrial applications. Microbial enzyme resource databases establish foundations for the mining, engineering, and utilization of new biocatalysts. This mini-review will briefly introduce the current development of enzyme databases and discuss the enzyme resources applications facilitated by databases.