梅毒螺旋体的营养物质转运及能量合成相关代谢机制研究

Metabolic mechanisms of nutrients transport and energy synthesis of Treponema pallidum

摘要:

梅毒螺旋体（Treponema pallidum，Tp）是严重危害人类健康的性传播疾病梅毒的病原体，目前仍难以实现体外人工培养。Tp在感染期间是如何获得足够的能量来完成其复杂的致病过程迄今不明。本文就Tp的葡萄糖转运、糖酵解途径、丙酮酸去路以及NAD⁺再生的研究进展做一综述，旨在为探索Tp尚未明了的生理代谢机能、突破Tp无法体外人工培养的瓶颈、进一步阐明Tp可能的致病机制和寻找新的临床治疗靶点提供依据。

关键词:梅毒螺旋体;糖酵解途径;ATP合成;NAD⁺;丙酮酸

Abstract:

Treponema pallidum is the pathogen of the sexually transmitted disease syphilis that seriously endangers the physical and mental health of humans, and it is still difficult to achieve artificial culture in vitro. A longstanding conundrum in Treponema pallidum biology concerns how the spirochete generates sufficient energy to fulfill its complex pathogenesis processes during human syphilitic infection. This article describes the metabolic mechanisms of Treponema pallidum, such as nutrients transport, glycolysis pathways, and metabolite detours, in order to arouse the attention of researchers and further explore the physiological and metabolic functions of Treponema pallidum that are not yet understood, and break the bottleneck of Treponema pallidum in vitro artificial culture. To clarify the possible pathogenic mechanism of Treponema pallidum, to find new clinical treatment targets to provide reference.

Key words:Treponema pallidum;glycolysis pathway;ATP synthesis;NAD⁺;pyruvate