基于代谢组学的抗生素与细菌间作用研究进展

Research progress of the interaction between antibiotics and bacteria based on metabolomics

摘要:

抗生素杀菌是一个复杂的生理过程，杀菌抗生素与靶点作用后的下游代谢变化与抗生素作用效果紧密联系，其通过干扰细菌代谢状态加速死亡进程，而细菌改变代谢状态也能影响抗生素的有效性。代谢组学通过监测细菌在抗生素作用下的变化提供全面代谢信息，我们回顾近年来基于代谢组学对抗生素与细菌间作用的研究进展，以期为开发抗生素佐剂提高抗生素效果提供参考。

Abstract:

Antibiotic killing is a complex physiological process. The downstream metabolic changes of antibiotic-target interactions are closely related to antibiotic efficacy. Bactericidal antibiotics speed up the death process by perturbing the bacterial metabolism, which also influences the antibiotic efficacy. Metabolomics provides comprehensive metabolic information for monitoring the changes of bacterial metabolism under the action of antibiotics. Here we review recent metabolomics-driven studies on the interaction between antibiotics and bacteria, intending to provide a reference for the development of antibiotic adjuvants to enhance the antibiotic efficacy.