白色念珠菌胞外囊泡的组成及其功能研究进展

Research progress on the composition and function of extracellular vesicles of Candida albicans

摘要:

口腔疾病研究国家重点实验室，国家口腔疾病临床医学研究中心，四川大学华西口腔医院牙体牙髓病科，四川成都610000

Abstract:

Candidiasis refers to the acute, subacute or chronic infection caused by Candida, which usually involves the skin and mucosa, as well as internal organs and various system organs, and can cause serious consequences. It is a deep mycosis with the highest incidence at present. Candida albicans is one of the most common opportunistic pathogenic fungi in Candida species. Recently, more and more studies have confirmed that the extracellular vesicles of Candida albicans play an important role in its pathogenicity. They are involved in the transport of important proteins and genetic materials, influence the drug resistance of Candida albicans, and communicate with host cells to mediate the inflammatory and immune responses of the host. Some studies have shown that extracellular vesicles have immune activity and can be used as a vaccine preparation. Therefore, this paper reviews the composition and function of extracellular vesicles of Candida albicans in order to provide reference for further research in the future.