益生菌对皮肤光老化的修复作用及其机制研究进展

Research progress on the mechanism of the repair of skin photoaging by probiotics

摘要:

皮肤是人体最大的器官，也是机体防御外界各种物理、化学及病原微生物侵害的重要组织。皮肤系统若出现老化，则导致其功能衰退、防御功能下降，危害机体健康。日常生活中，各类光照时刻侵害着我们的皮肤，加速其老化的速度。研究指出，光照尤其是日光中的紫外辐射可通过直接损伤DNA、产生活性氧、降解细胞外基质和诱发炎症等多种方式损伤皮肤细胞，导致皮肤功能的下降。近年来，越来越多的研究发现微生态对于皮肤健康有重要影响，而益生菌作为调节皮肤微生态平衡的手段，通过抗氧化、减少细胞外基质降解和抑制炎症因子的表达，延缓皮肤光老化。本文系统综述了皮肤光老化的机制与益生菌抵抗光老化的研究进展，进而探讨益生菌改善皮肤健康的应用模式，以期对益生菌在皮肤抗光老化应用提供参考。

关键词:皮肤;光老化;益生菌;氧化损伤;抗氧化

Abstract:

The skin, the largest organ of the human body, is the first defense line of the immune system. Aging of the skin may lead to dysfunction and weakened protection for our body, causing a series of health problems. Lights, especially the ultraviolet, may accelerate skin aging and destroy our skin barrier. Researchers have demonstrated that ultraviolet can directly damage the DNA and RNA in the skin cells and induce the generation of reactive oxygen species, leading to lipid peroxidation, extra-cellular matrix degradation, and inflammation, all of which ultimately accelerate skin photoaging. Growing evidence has proved the importance of microbiome to skin health, and probiotics may modulate the skin ecology and postpone skin aging through generating anti-oxidative metabolites, inhibiting the activities of matrix metalloproteinases, and reducing inflammatory cytokines. In this review, we summarized the mechanisms of skin photoaging as well as the cutting-edge studies of probiotics against skin photoaging and discussed the potential application of probiotics, aiming to provide a reference for the application of probiotics in the alleviation of skin photoaging.

Key words:skin;photoaging;probiotics;oxidative damage;antioxidation