细菌DeoR家族转录调控因子的研究进展

Progress on the DeoR family transcriptional regulators in bacteria

摘要:

细菌基因组中存在大量的转录调控家族，这些转录调控家族在细菌的生长、代谢、外界信号感知与传递等方面发挥着至关重要的作用。DeoR家族是一类广泛分布于原核生物中的转录调控因子，主要参与调控细胞中多个生理过程，包括核苷酸类代谢、糖类代谢、致病菌的毒力以及链霉菌的次级代谢等。DeoR蛋白C末端的配体结合结构域，通常能够以相关代谢途径的磷酸化中间体作为配体。本文综述了细菌中DeoR家族转录调控因子的结构特征、调控功能以及响应的配体分子，以期为深入研究DeoR家族蛋白的分子调控机制提供参考。

关键词:DeoR家族转录调控因子;结构特征;调控功能;靶序列;配体

Abstract:

There are a large number of transcriptional regulator families in bacterial genomes, which play a crucial role in the growth, metabolism, and external signal perception and transmission of bacteria. Deoxyribonucleoside operon repressor (DeoR) family, a category of transcriptional regulators ubiquitous in prokaryotes, is mainly involved in the regulation of multiple physiological processes, including nucleotide metabolism, sugar metabolism, pathogenesis, and secondary metabolism. The ligand-binding domain at the C-terminus of DeoR usually responds to phosphorylated intermediate of the corresponding metabolic pathway. This paper reviewed the structural features, regulatory function, and ligands of DeoR family transcriptional regulators in bacteria, aiming to help researchers to decipher the regulatory mechanisms of DeoR proteins.

Key words:deoxyribonucleoside operon repressor;structural feature;regulatory function;target sequence;ligand