NLRP6在感染性和非感染性疾病中的作用

Role of NLRP6 in infectious and non-infectious diseases

摘要:

核苷酸结合寡聚化结构域样受体含pyrin结构域蛋白6(NLRP6)属于核苷酸结合寡聚化结构域样受体(NLRs)家族蛋白。NLRP6可以作为受体蛋白参与炎症小体的组装,引起白细胞介素IL-1β和IL-18的成熟与分泌。NLRP6在病原体感染诱导宿主天然免疫应答中发挥重要作用。此外,NLRP6在维持肠道上皮完整、调控代谢性疾病及神经性炎症等方面也发挥重要功能。本文将对NLRP6炎症小体的激活与调控机制、NLRP6在感染性和非感染性疾病中的作用等研究进展进行综述。

关键词:NLRP6;炎症小体;宿主防御

Abstract:

Nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 6(NLRP6) is a member of the NOD-like receptor (NLR) family.It participates in inflammasome assembly to mediate the maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18.In addition,it plays an important role in host innate immune response to pathogen,maintaining intestinal epithelial integrity,and regulating metabolic diseases and neuroinflammation.In this paper,we reviewed the activation and regulation mechanism of NLRP6 inflammasome,as well as the role of NLRP6 in infectious and non-infectious diseases.

Key words:NLRP6;inflammasome;host defense