EV71抗病毒药物及疫苗研究进展

Research progress of drugs and vaccines against enterovirus 71

摘要:

手足口病(hand-foot and mouth disease,HFMD)作为全球关注的公共卫生疾病,亚洲地区频发,危害不容小觑。其传播途径广、传染性强、易引起并发症,致病株多样且易变异等特点,均为手足口病的治疗与防控带来挑战。肠道病毒71型(human enterovirus 71,EV71)作为手足口病主要的病原体之一,目前没有特效的抗病毒药物,故寻求合适的治疗药物极其重要。本文就EV71的抗病毒药物和疫苗研究进展进行总结,为手足口病的防控提供方向。

Abstract:

Hand-foot and mouth disease (HFMD),as a disease of global concern,occurs frequently in Asia and its harm cannot be underestimated.The multiple transmission routes,strong infectivity,induction of complications,diverse pathogenic strains and easy variation bring challenges to the prevention and treatment of HFMD.Enterovirus 71(EV71) is one of the main pathogens causing HFMD.Since there is no specific drug against EV71,it is of great significance to find appropriate therapeutic drugs.We summarize the research progress of drugs and vaccines against EV71,aiming to give insights into the prevention and control of HFMD.