链霉菌的全局调控蛋白DasR

Global regulatory protein DasR in Streptomyces

摘要:

链霉菌能够产生多种次级代谢产物,在临床、农牧业、生物技术等领域具有重要应用价值;对链霉菌的调控网络进行深入研究有助于提高次级代谢产物产量并发现新的次级代谢产物。链霉菌中次级代谢产物生物合成按调控通路分为全局调控与途径特异性调控,其中全局调控蛋白可靶向多种通路特异调控基因和生物合成基因,在链霉菌的生命活动中发挥着更为普遍、复杂的调控作用,因此研究全局调控对于进一步认识链霉菌复杂调控网络具有重要的意义。DasR作为一个全局调控蛋白,在链霉菌的营养感应、形态分化和次级代谢中发挥重要作用,本文从DasR的结构、序列和作用特点出发,联系链霉菌生长发育和次级代谢、营养感应和初级代谢等讨论DasR的研究进展。

Abstract:

Streptomycetes produce a variety of secondary metabolites,which are highly valuable in clinical practice,agriculture,animal husbandry,biotechnology,etc.The research on the regulatory networks of secondary metabolites in Streptomycetes will improve their yields and facilitate the discovery of novel secondary metabolites.The biosynthesis of secondary metabolites in Streptomycetes can be regulated in a global or pathway-specific manner.The global regulators can target multiple pathway-specific genes and biosynthesis genes,playing a universal and complicated role.Therefore,studying the global regulation will improve the understanding of the complicated regulation networks in Streptomycetes.DasR,a global regulator,plays a key role in the nutrient sensing,morphological changing,and secondary metabolism.In this review,we summarized the structure,sequence,and function of DasR,and reviewed the research findings on role of DasR in the growth,secondary metabolism,nutrient sensing,and primary metabolism of Streptomycetes.