耐药细菌中交互敏感现象研究进展

Advance in collateral sensitivity in drug-resistant bacteria

摘要:

细菌耐药性是全球亟待解决的重要公共卫生问题之一，耐药病原菌对人类和动物健康构成极大威胁。交互敏感性、附带敏感性(collateral sensitivity)是指耐药细菌在进化过程中出现的对一类抗菌药物耐药，而对另一类或几类抗菌药物更加敏感的现象。利用交互敏感策略限制甚至逆转细菌耐药性以恢复其对抗菌药物的敏感性是细菌耐药性研究的热点。本文综述了细菌交互敏感的最新研究进展，主要从交互敏感性的概念、表型及机制研究等方面进行阐述，以期为防控和治疗耐药病原菌感染提供新思路。

Abstract:

Antibiotic resistance is one of the global conundrums. Multi-drug resistant (MDR) bacteria-associated infections pose a great threat to the health of both human and animals. Collateral sensitivity is a phenomenon that the bacteria developed resistance to one antibiotic display increased susceptibility to a second antibiotic. Collateral sensitivity has been intensively explored to restrict and/or reverse the evolutionary trajectory of resistance bacteria in the past years. This review mainly focuses on the concept, phenotypes, and molecular mechanisms of collateral sensitivity, to shed light on the development of alternative approaches to treating MDR bacteria.