高抗菌活性乳酸菌拮抗食源性致病菌的研究进展

High antibacterial activity of lactic acid bacteria against food-borne pathogens

摘要:

食源性致病菌严重威胁人类的生命健康。服用抗生素是目前最有效的治疗手段。但不规范使用抗生素，导致耐药性细菌日趋普遍。乳酸菌是公认的食品级安全微生物，因其具有拮抗致病菌、增强免疫功能、加强肠道屏障、平衡肠道菌群等功能而具有良好的应用前景，有望成为下一代安全、稳定、经济的生物抗菌剂，以减少甚至替代抗生素的使用。本文通过阐述乳酸菌抗菌物质、抗菌机制及抗菌功能特性等，以促进乳酸菌的研究和应用。

关键词:乳酸菌;食源性致病菌;抗菌机制;抗菌物质

Abstract:

Food-borne pathogens threaten human life and health and antibiotics are the most effective choice at the moment.However,the irregular use of antibiotics has led to the rising prevalence of drug-resistant bacteria.Lactic acid bacteria are recognized as safe food-grade microorganisms.They boast good application prospects attributing to the functions of antagonizing pathogenic bacteria,improving immune regulation,strengthening intestinal barrier,and balancing intestinal microbiota.They are expected to become the next generation of safe,stable,and economical biological antibacterials to reduce or even replace antibiotics.This article describes the antibacterial substances,antibacterial mechanisms,and antibacterial functional properties of lactic acid bacteria to promote the research on and application of them.

Key words:lactic acid bacteria;food-borne pathogens;antibacterial mechanism;antibacterial substance