中药抗白念珠菌研究新进展

Chinese medicine against Candida albicans

摘要:

以白念珠菌为主的真菌感染近年来呈上升态势，氟康唑等一线抗真菌药物因长期应用导致耐药菌株不断出现，中药在抗真菌感染方面具有独特的优势。本课题组在多项国家与省级课题资助下，对中药的体内外抗真菌作用及机制进行了较系统深入的研究，现结合课题组自身与国内外在中药抗真菌感染领域的最新研究成果，对中药抗真菌(主要是白念珠菌)近5年的研究进展进行综述。

关键词:中药;白念珠菌;黏附;形态转换;生物膜;水解酶;感染

Abstract:

Fungal infections (mycoses) have been on the rise and fungal pathogens have gradually developed drug resistance amid the long-term use of conventional antifungal drugs such as fluconazole. Chinese medicine is superior in anti-fungal infection. Our research group has been carrying out systematic and in-depth research on the in vivo and in vitro effects and mechanisms of antifungal Chinese medicine with the support of a number of national and provincial projects. Therefore, on the basis of the latest research outcomes in Chinese medicine’s anti-fungal infection of our research group and others in China and abroad, we summarize the research on Chinese medicine combating fungi (mainly Candida albicans) in the past five years.

Key words:Chinese medicine;Candida albicans;adhesion;dimorphic switch;biofilms;hydrolytic enzymes;infection