中药抗白念珠菌研究新进展

Chinese medicine against Candida albicans

摘要:

以白念珠菌为主的真菌感染近年来呈上升态势，氟康唑等一线抗真菌药物因长期应用导致耐药菌株不断出现，中药在抗真菌感染方面具有独特的优势。本课题组在多项国家与省级课题资助下，对中药的体内外抗真菌作用及机制进行了较系统深入的研究，现结合课题组自身与国内外在中药抗真菌感染领域的最新研究成果，对中药抗真菌(主要是白念珠菌)近5年的研究进展进行综述。

Abstract:

Fungal infections (mycoses) have been on the rise and fungal pathogens have gradually developed drug resistance amid the long-term use of conventional antifungal drugs such as fluconazole. Chinese medicine is superior in anti-fungal infection. Our research group has been carrying out systematic and in-depth research on the in vivo and in vitro effects and mechanisms of antifungal Chinese medicine with the support of a number of national and provincial projects. Therefore, on the basis of the latest research outcomes in Chinese medicine’s anti-fungal infection of our research group and others in China and abroad, we summarize the research on Chinese medicine combating fungi (mainly Candida albicans) in the past five years.