微生物疗法中工程菌的信号感知及其在生物医学中的应用
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国家重点研发计划青年科学家项目(2019YFA0906500);国家自然科学基金优秀青年基金(32122047)


Signal sensing of engineered bacteria in microbial therapy and its application in biomedicine
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  • LIU Baona

    LIU Baona

    School of Life Sciences, Tianjin University, Tianjin 300072, China;Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, Tianjin 300072, China
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  • WANG Hanjie

    WANG Hanjie

    School of Life Sciences, Tianjin University, Tianjin 300072, China;Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, Tianjin 300072, China
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    摘要:

    近年来,基于微生物能够提供健康益处的事实而兴起的微生物疗法为多种疾病的诊疗提供了新的契机。研究表明临床上口服乳酸菌、大肠杆菌和双歧杆菌可用于辅助治疗各种疾病。在微生物疗法中,工程菌因能够发挥特定功能而备受关注,即可通过感知疾病环境中的特定信号分子实现辅助诊断,也可实现靶向疾病部位感知特定信号,通过时空调控启动自身表达系统释放特定分子以实现精准治疗的目的。本文主要对工程菌对不同信号分子的感知系统及其在生物医学领域的应用进行了综述。

    Abstract:

    In recent years, microbial therapy based on the fact that microorganisms can provide health benefits has created new opportunities for the diagnosis and treatment of diseases. Studies have demonstrated that oral administration of Lactobacillus lactis, Escherichia coli, and Bifidobacterium can assist in the treatment of a variety of diseases. In microbial therapy, engineered bacteria have attracted much attention owing to their specific functions. They can either assist in diagnosis by sensing specific signaling molecules in the disease environment, or target the specific signals of the disease site and initiate their expression systems to release specific molecules for precise treatment. This paper reviewed the sensing systems of engineered bacteria for different signaling molecules and the application of the sensing systems in biomedicine.

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刘宝娜,王汉杰. 微生物疗法中工程菌的信号感知及其在生物医学中的应用[J]. 微生物学报, 2023, 63(1): 124-138

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历史
  • 收稿日期:2022-05-11
  • 最后修改日期:2022-07-15
  • 在线发布日期: 2023-01-13
  • 出版日期: 2023-01-04
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