嗜盐古菌启动子的研究及应用

Research and application of haloarchaeal promoter

摘要:

嗜盐古菌是古菌域的一个重要代表类群，在遗传与代谢、进化与适应、前沿生物技术及合成生物学领域都显示了其重要的研究价值。嗜盐古菌启动子的认识和利用，可以为嗜盐古菌的基础和应用研究提供必要的条件。本文从古菌启动子的结构与功能出发，就启动子的研究方法、嗜盐古菌启动子的特征及嗜盐古菌启动子的应用3个方面综述了嗜盐古菌启动子的研究现状，并对嗜盐古菌启动子未来研究的重点和方向进行了展望。

关键词:嗜盐古菌;启动子;诱导型启动子;组成型启动子

Abstract:

Halophilic archaea are an important group in the domain archaea. They are of great value in the fields of genetics and metabolism, evolution and adaptation, technology frontier and synthetic biology. Haloarchaeal promoter is indispensable for both fundamental and applied research on halophilic archaea. In this paper, we first described the structure and functions of archaeal promoter in transcription. Then, we summarized and discussed the research achievements in haloarchaeal promoter from the following three aspects: the methods for studying promoter, the constitutive and inducible haloarchaeal promoters reported so far, and their applications. The challenges and future research focusing on mining, designing, developing, and optimizing haloarchaeal promoter were also prospected.

Key words:halophilic archaea;promoters;inducible promoters;constitutive promoters