鼠疫减毒活疫苗研究现状与展望

Live-attenuated Yersinia pestis vaccines

摘要:

鼠疫(plague)是由鼠疫耶尔森氏菌(Yersinia pesits)引起的烈性传染病，在人类历史上曾造成约2亿人的死亡，在我国被列为甲类传染病。由于鼠疫菌具有高度致病性、传染性，被列为最具潜力的生物战剂和生物恐怖剂。在面临鼠疫威胁时，疫苗是最为有力的武器。鼠疫疫苗研究中，减毒活疫苗是重要的研究方向，现就鼠疫减毒活疫苗的研究现状进行综述，为新疫苗的研制提供参考。

Abstract:

Plague caused by Yersinia pestis is a fulminating infectious disease, resulting in nearly 200 million deaths in human history. It is listed as a category A infectious disease in China. As a highly infectious pathogen, Y. pestis is considered one of the most potential biological weapons and biothreat agents. Prophylactic vaccination is a powerful measure for counteracting this disease. In the development of plague vaccines, live-attenuated vaccine is an important research direction. This review introduces the recent progress, current challenges, as well as the future prospects on the development of live-attenuated plague vaccines.