念珠菌—上皮细胞互作研究进展

Candida-epithelial interactions

摘要:

念珠菌作为共生菌定植于机体黏膜表面，一般情况下并不引起感染，但当机体出现免疫力下降或微生态失衡等状况时，可引发口咽念珠菌病、外阴阴道念珠菌病等黏膜感染。对于念珠菌黏膜感染的治疗，虽然抗菌药物是不可或缺的因素，但宿主自身的免疫力，尤其是黏膜上皮细胞作为抵御念珠菌感染的第一道防线，发挥着重要作用。本文将念珠菌—上皮细胞相互作用研究进展作一综述。

Abstract:

Candida normally colonizes mucosal surfaces without causing any problems. Sometimes, it causes mucosal infections such as oropharyngeal candidiasis and vulvovaginal candidiasis in individuals with compromised immunity or microecological imbalance. For the treatment of the infections, antifungal agents are indispensable, and the host՚s immunity, especially mucosal epithelial cells as the first line of defense against Candida infection, plays an important role. In this paper, we summarize the research on the Candida-epithelial interactions.