念珠菌—上皮细胞互作研究进展
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基金项目:

国家自然科学基金(81774034,81573725);安徽省重点研究与开发计划项目(202104a07020020);安徽省自然科学基金(1908085MH291);安徽省教育厅重点项目(KJ2021A0590)


Candida-epithelial interactions
Author:
  • WANG Tianming

    WANG Tianming

    College of Integrated Chinese and Western Medicine (College of Life Science), Anhui University of Chinese Medicine, Hefei 230012, Anhui, China;Institute of Integrated Traditional Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei 230012, Anhui, China;School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China
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  • SHI Gaoxiang

    SHI Gaoxiang

    College of Integrated Chinese and Western Medicine (College of Life Science), Anhui University of Chinese Medicine, Hefei 230012, Anhui, China;Institute of Integrated Traditional Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei 230012, Anhui, China
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  • WU Daqiang

    WU Daqiang

    College of Integrated Chinese and Western Medicine (College of Life Science), Anhui University of Chinese Medicine, Hefei 230012, Anhui, China;Institute of Integrated Traditional Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei 230012, Anhui, China
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  • SHAO Jing

    SHAO Jing

    College of Integrated Chinese and Western Medicine (College of Life Science), Anhui University of Chinese Medicine, Hefei 230012, Anhui, China;Institute of Integrated Traditional Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei 230012, Anhui, China
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  • WANG Changzhong

    WANG Changzhong

    College of Integrated Chinese and Western Medicine (College of Life Science), Anhui University of Chinese Medicine, Hefei 230012, Anhui, China;Institute of Integrated Traditional Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei 230012, Anhui, China
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    摘要:

    念珠菌作为共生菌定植于机体黏膜表面,一般情况下并不引起感染,但当机体出现免疫力下降或微生态失衡等状况时,可引发口咽念珠菌病、外阴阴道念珠菌病等黏膜感染。对于念珠菌黏膜感染的治疗,虽然抗菌药物是不可或缺的因素,但宿主自身的免疫力,尤其是黏膜上皮细胞作为抵御念珠菌感染的第一道防线,发挥着重要作用。本文将念珠菌—上皮细胞相互作用研究进展作一综述。

    Abstract:

    Candida normally colonizes mucosal surfaces without causing any problems. Sometimes, it causes mucosal infections such as oropharyngeal candidiasis and vulvovaginal candidiasis in individuals with compromised immunity or microecological imbalance. For the treatment of the infections, antifungal agents are indispensable, and the host՚s immunity, especially mucosal epithelial cells as the first line of defense against Candida infection, plays an important role. In this paper, we summarize the research on the Candida-epithelial interactions.

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引用本文

汪天明,施高翔,吴大强,邵菁,汪长中. 念珠菌—上皮细胞互作研究进展[J]. 微生物学报, 2023, 63(3): 918-931

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  • 收稿日期:2022-07-15
  • 录用日期:2022-09-14
  • 在线发布日期: 2023-03-08
  • 出版日期: 2023-03-04
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